U-net and its variants for medical image segmentation: A review of theory and applications

U-net is an image segmentation technique developed primarily for image segmentation tasks. These traits provide U-net with a high utility within the medical imaging community and have resulted in extensive adoption of U-net as the primary tool for segmentation tasks in medical imaging. The success of U-net is evident in its widespread use in nearly all major image modalities, from CT scans and MRI to Xrays and microscopy. Furthermore, while U-net is largely a segmentation tool, there have been instances of the use of U-net in other applications. Given that U-net’s potential is still increasing, this narrative literature review examines the numerous developments and breakthroughs in the U-net architecture and provides observations on recent trends. We also discuss the many innovations that have advanced in deep learning and discuss how these tools facilitate U-net. In addition, we review the different image modalities and application areas that have been enhanced by U-net

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Short-term changes in spruce foliar nutrients and soil properties in response to wood ash application in the sub-boreal climate zone of British Columbia

Utilization of wood ash as a forest soil amendment in British Columbia could have numerous benefits, including potentially increasing tree growth. Two wood-derived bottom ashes (low carbon gasifier ash and high carbon boiler ash) were applied at 5000 kg ha-1 (dry weight equivalent) with urea (100 kg N ha-1), in a two-way factorial randomized block design across two (18- and 24-year-old) hybrid spruce (Picea glauca X engelmannii Parry x Engelm.) plantations in interior British Columbia. Changes in spruce foliar nutrients and selected soil properties were evaluated. After one growing-season, foliar Ca and S significantly increased in plots treated with ash, and foliar N significantly increased while foliar Mg and P significantly decreased in spruce treated with urea. In LFH horizons, soil pH, exchangeable base cations (Ca, Mg, K), strong acid extractable B and Ca significantly increased (pThe accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author